Ontology highlight
ABSTRACT:
SUBMITTER: Devkota AK
PROVIDER: S-EPMC6535306 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
Devkota Ashwini K AK Veloria John R JR Guo Hou-Fu HF Kurie Jonathan M JM Cho Eun Jeong EJ Dalby Kevin N KN
SLAS discovery : advancing life sciences R & D 20181227 4
Lysyl hydroxylase-2 (LH2) catalyzes the hydroxylation of telopeptidyl lysine residues on collagen, leading to the formation of stable collagen cross-links that connect collagen molecules and stabilize the extracellular matrix. High levels of LH2 have been reported in the formation and stabilization of hydroxylysine aldehyde-derived collagen cross-links (HLCCs), leading to fibrosis and cancer metastasis in certain tissues. Identification of small-molecule inhibitors targeting LH2 activity require ...[more]