Viremia copy-years and mortality among combination antiretroviral therapy-initiating HIV-positive individuals: how much viral load history is enough?

ABSTRACT:

Objective

Ongoing HIV replication while receiving combination antiretroviral therapy (cART) may reduce survival. Viremia copy-years (VCY) has shown improved mortality risk prediction over single time-point viral load measures. However, the timing of a patient's viral load history most associated with later mortality has not been studied. Here we determined the optimal duration and temporality of viral load history for predicting mortality.

Design

Survival analysis among HIV-positive men who initiated cART in the Multicenter AIDS Cohort Study (1995-2015).

Methods

VCY measures were derived from area-under-the-viral load-curve. The overall VCY based upon the complete post-cART viral load history was compared with 20 VCYs derived from viral loads assessed during different

SUBMITTER: Wang R 

PROVIDER: S-EPMC6535334 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature