Ontology highlight
ABSTRACT:
SUBMITTER: Xia B
PROVIDER: S-EPMC6535506 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
Xia Bin B Li Mei M Tian Zhenyang Z Chen Gukui G Liu Chang C Xia Yushan Y Jin Yongxin Y Bai Fang F Cheng Zhihui Z Jin Shouguang S Wu Weihui W
Antimicrobial agents and chemotherapy 20190524 6
<i>Pseudomonas aeruginosa</i> is an opportunistic bacterial pathogen and is intrinsically resistant to a variety of antibiotics. Oligoribonuclease (Orn) is a 3'-to-5' exonuclease that degrades nanoRNAs. The Orn controls biofilm formation by influencing the homeostasis of cyclic-di-GMP. Previously, we demonstrated that Orn contributes to the tolerance of <i>P. aeruginosa</i> to fluoroquinolone antibiotics by affecting the production of pyocins. In this study, we found that mutation in the <i>orn< ...[more]