Pulmonary Pharmacokinetics of Oseltamivir Carboxylate in Rats after Nebulization or Intravenous Administration of Its Prodrug, Oseltamivir Phosphate.
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ABSTRACT:
SUBMITTER: Carrez R
PROVIDER: S-EPMC6535510 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
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Pulmonary Pharmacokinetics of Oseltamivir Carboxylate in Rats after Nebulization or Intravenous Administration of Its Prodrug, Oseltamivir Phosphate.
Carrez Romain R Brillault Julien J Grégoire Nicolas N Lamarche Isabelle I Laroche Julian J Couet William W Marchand Sandrine S
Antimicrobial agents and chemotherapy 20190524 6
The aim of this study was to investigate the pharmacokinetics of oseltamivir phosphate, a prodrug, and its active moiety in plasma and lung after its nebulization and intravenous administration in rats. Only 2% of prodrug was converted into active moiety presystematically, attesting to a low advantage of oseltamivir phosphate nebulization, suggesting that oseltamivir phosphate nebulization is not a good option to obtain a high exposure of the active moiety at the infection site within lung. ...[more]
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