Dataset Information

Clinical outcomes of patients receiving prolonged extracorporeal membrane oxygenation for respiratory support.

ABSTRACT:

Background

There are limited data regarding prolonged extracorporeal membrane oxygenation (ECMO) support, despite increase in ECMO use and duration in patients with respiratory failure. The objective of this study was to investigate the outcomes of severe acute respiratory failure patients supported with prolonged ECMO for more than 28?days.

Methods

Between January 2012 and December 2015, all consecutive adult patients with severe acute respiratory failure who underwent ECMO for respiratory support at 16 tertiary or university-affiliated hospitals in South Korea were enrolled retrospectively. The patients were divided into two groups: short-term group defined as ECMO for ?28?days and long-term group defined as ECMO for more than 28?days. In-hospital and 6-month mortalities were compared between the two groups.

Results

A total of 487 patients received ECMO support for acute respiratory failure during the study period, and the median support duration was 8?days (4-20?days). Of these patients, 411 (84.4%) received ECMO support for ?28?days (short-term group), and 76 (15.6%) received support for more than 28?days (long-term group). The proportion of acute exacerbation of interstitial lung disease as a cause of respiratory failure was higher in the long-term group than in the short-term group (22.4% versus 7.5%, p?ConclusionsShort- and long-term survival rates among patients receiving ECMO support for more than 28?days for severe acute respiratory failure were not worse than those among patients receiving ECMO for 28?days or less.

SUBMITTER: Na SJ

PROVIDER: S-EPMC6535699 | biostudies-literature | 2019 Jan-Dec

REPOSITORIES: biostudies-literature

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Publications

Clinical outcomes of patients receiving prolonged extracorporeal membrane oxygenation for respiratory support.

Na Soo Jin SJ Jung Jae-Seung JS Hong Sang-Bum SB Cho Woo Hyun WH Lee Sang-Min SM Cho Young-Jae YJ Park Sunghoon S Koo So-My SM Park Seung Yong SY Chang Youjin Y Kang Byung Ju BJ Kim Jung-Hyun JH Oh Jin Young JY Park So Hee SH Yoo Jung-Wan JW Sim Yun Su YS Jeon Kyeongman K

Therapeutic advances in respiratory disease 20190101

<h4>Background</h4>There are limited data regarding prolonged extracorporeal membrane oxygenation (ECMO) support, despite increase in ECMO use and duration in patients with respiratory failure. The objective of this study was to investigate the outcomes of severe acute respiratory failure patients supported with prolonged ECMO for more than 28 days.<h4>Methods</h4>Between January 2012 and December 2015, all consecutive adult patients with severe acute respiratory failure who underwent ECMO for r ...[more]

PMID: 31090503

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Project description:BackgroundExtracorporeal membrane oxygenation (ECMO) is an important rescue therapy for patients with refractory respiratory or circulatory failure. High cost and associated complications warrant careful case selection. The aim of this study was to investigate the outcomes and factors associated with mortality in acute hypoxemic respiratory failure patients who received ECMO support, and to externally validate preexisting ECMO survival prediction scoring systems.MethodsThis retrospective study enrolled acute hypoxemic respiratory failure patients who received veno-venous (VV) or veno-arterial (VA) ECMO support at Siriraj Hospital (Bangkok, Thailand) from 2010 to 2020. All relevant baseline patient characteristics including ECMO survival prediction scores were recorded. The primary outcome was in-hospital mortality. Multivariate logistic regression analysis was employed to identify independent predictors of in-hospital mortality.ResultsOf a total of 65 patients, 34 (52%) were male, the median (IQR) age was 61 years (49-70 years), the median body mass index (BMI) was 22.6 kg/m2 (20.6-28 kg/m2), and the median Sequential Organ Failure Assessment (SOFA) score was 13 [11-16]. Forty-three patients (66%) received VV-ECMO, and 22 (34%) received VA-ECMO support. In-hospital mortality was 69%. Multivariate analysis identified a SOFA score >14, hospitalized >72 hours before ECMO initiation, PaO2/FiO2 ratio <60, and pH <7.2 as independent predictors of in-hospital mortality. These four parameters were combined to create the SHOP (S: SOFA >14, H: hospitalize >72 hours, O: PF ratio <60, and P: pH <7.2) score. Compared with three different preexisting ECMO survival prediction scoring systems, the SHOP score had the highest area under the curve (AUC) for predicting in-hospital mortality (overall: 0.873, VV-EMCO: 0.866, and VA-EMCO: 0.891).ConclusionsIn-hospital mortality among ECMO-supported patients was high at 69%. SOFA score >14, hospitalized >72 hours, PaO2/FiO2 ratio <60, and pH <7.2 were found to be independent predictors of in-hospital mortality. A SHOP score of 2 or higher significantly predicts in-hospital mortality in EMCO-supported patients.Trial registrationwww.clinicaltrials.gov (reg. No. NCT04031794).

Dataset Information

Clinical outcomes of patients receiving prolonged extracorporeal membrane oxygenation for respiratory support.

Background

Methods

Results

Publications

Clinical outcomes of patients receiving prolonged extracorporeal membrane oxygenation for respiratory support.

Similar Datasets

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