Chemokines in hyperthyroidism.
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ABSTRACT:
SUBMITTER: Ferrari SM
PROVIDER: S-EPMC6536457 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
Publications
Chemokines in hyperthyroidism.
Ferrari Silvia Martina SM Ruffilli Ilaria I Elia Giusy G Ragusa Francesca F Paparo Sabrina Rosaria SR Patrizio Armando A Mazzi Valeria V Antonelli Alessandro A Fallahi Poupak P
Journal of clinical & translational endocrinology 20190517
The term "hyperthyroidism" indicates a condition due to an exaggerate production of thyroid hormone; the most frequent cause is Graves' disease (GD). We review cytokines and chemokines in hyperthyroidism, with a special focus in GD. In GD, recruited Th1 lymphocytes are responsible for enhanced IFN-γ and TNF-α production, which in turn stimulates Th1 chemokines release from thyrocytes, initiating and perpetuating the autoimmune process. Circulating levels of these chemokines are associated with t ...[more]
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