Ontology highlight
ABSTRACT:
SUBMITTER: Wang J
PROVIDER: S-EPMC6536923 | biostudies-literature | 2019 May
REPOSITORIES: biostudies-literature
Wang Jiayu J Li Weiwei W Shi Yujian Y Huang Yan Y Sun Tao T Tang Lili L Lu Qing Q Lei Qiumo Q Liao Ning N Jin Feng F Li Hui H Huang Tao T Qian Jun J Pang Danmei D Wang Shusen S Fan Peizhi P Wu Xinhong X Lin Ying Y Qin Haiyan H Xu Binghe B
Cancer medicine 20190413 5
Genetic testing for germline mutations in BRCA1/2 of patients with breast cancer (BC) is part of routine patient care. However, BRCA1/2 mutations account only for a fraction of familial BC. A custom panel of 22 gene sequencing was performed on each patient. Among the 481 female patients, 135 patients were detected to carry pathogenic (P)/likely pathogenic (LP) mutations (28.1%), which corresponded to 12 different cancer predisposition genes [14.6% (70/481) on BRCA1 gene, 5.0% (24/481) on BRCA2 g ...[more]