Expression Profiling and Clinical Significance of Plasma MicroRNAs in Diabetic Nephropathy.

ABSTRACT:

Aims

MicroRNAs (miRNAs) stably and abundantly exist in body fluids and have been considered as novel and noninvasive biomarkers for several diseases. The present study is aimed at investigating the expression profiling and clinical significance of plasma miRNAs in the pathogenesis and progression of diabetic nephropathy (DN).

Methods

Plasma samples were obtained from 66 DN patients (36 had microalbuminuria and 30 had macroalbuminuria), 36 diabetic patients with normoalbuminuria, and 40 healthy controls. The plasma miRNA profiles were obtained by miRNA low-density array chip and validated by quantitative real-time polymerase chain reaction. The correlations between the differential expression of plasma miRNAs and clinicopathological parameters were explored.

Results

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SUBMITTER: Wang J 

PROVIDER: S-EPMC6536987 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature