Ontology highlight
ABSTRACT:
SUBMITTER: Larssen E
PROVIDER: S-EPMC6537061 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Larssen Eivind E Brede Cato C Hjelle Anne A Tjensvoll Anne Bolette AB Norheim Katrine Brække KB Bårdsen Kjetil K Jonsdottir Kristin K Ruoff Peter P Omdal Roald R Nilsen Mari Mæland MM
SAGE open medicine 20190513
<h4>Objectives</h4>Fatigue is a frequent and often disabling phenomenon that occurs in patients with chronic inflammatory and immunological diseases, and the underlying biological mechanisms are largely unknown. Because fatigue is generated in the brain, we aimed to investigate cerebrospinal fluid and search for molecules that participate in the pathophysiology of fatigue processes.<h4>Methods</h4>A label-free shotgun proteomics approach was applied to analyze the cerebrospinal fluid proteome of ...[more]