Dataset Information

Characteristics of Brazilian melanomas: real-world results before and after the introduction of new therapies.

ABSTRACT:

Objective

This study is a characterization of the treatment patterns and outcomes of a Brazilian melanoma cohort collected of 1848 patients enrolled between 1996 and 2015.

Results

The superficial spreading subtype (35.1%) was the most prevalent, and the favoured anatomical location was the trunk (32.8%). The most common clinical stage was I (27.6%). The most frequent initial treatment was surgery (84.7%). Sentinel node biopsy was positive in 23.3% of cases. Chemotherapy was used to treat 298 patients (16.1%), immunotherapy for 67 (3.6%) and targeted therapy for 19 (1.0%). Distant recurrence was commonly observed (22.5%) and the mutation status of the BRAF gene was verified in 132 cases, with 42.4% positivity in this subset of patients. The melanoma specific actuarial 5-year survival for the cohort was 68.8%. There was a higher 5-year survival observed in metastatic melanoma patients who received immunotherapy and/or targeted therapy (34.2%) compared patients treated with just chemotherapy (20.0%). The survival analysis showed that sex, age, Breslow, clinical stage and distant recurrence were significant prognostic factors. This study provides a real-world description of how the introduction of new therapies such as immunotherapy and BRAF inhibitors is changing treatment strategies for melanoma in developing countries.

SUBMITTER: da Costa LMM

PROVIDER: S-EPMC6537357 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Characteristics of Brazilian melanomas: real-world results before and after the introduction of new therapies.

da Costa Letícia Maria Modes LMM Crovador Camila de Souza CS de Carvalho Carlos Eduardo Barbosa CEB Vazquez Vinicius de Lima VL

BMC research notes 20190528 1

<h4>Objective</h4>This study is a characterization of the treatment patterns and outcomes of a Brazilian melanoma cohort collected of 1848 patients enrolled between 1996 and 2015.<h4>Results</h4>The superficial spreading subtype (35.1%) was the most prevalent, and the favoured anatomical location was the trunk (32.8%). The most common clinical stage was I (27.6%). The most frequent initial treatment was surgery (84.7%). Sentinel node biopsy was positive in 23.3% of cases. Chemotherapy was used t ...[more]

PMID: 31138295

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Dataset Information

Characteristics of Brazilian melanomas: real-world results before and after the introduction of new therapies.

Objective

Results

Publications

Characteristics of Brazilian melanomas: real-world results before and after the introduction of new therapies.

Similar Datasets

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