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Lack of association between PAX6/SOSTDC1/FAM20B gene polymorphisms and mesiodens.

ABSTRACT: BACKGROUND:The purpose of this study was to analyze the association between the genetic polymorphism of genes (PAX6, SOSTDC1and FAM20B) and the susceptibility to mesiodens. METHODS:This study was carried out on 50 patients with mesiodens and 50 controls. The family history of each patient with mesiodens were recorded. Genomic DNA was extracted from saliva samples, and single nucleotide polymorphisms were detected in all exons and exon/intron boundaries of PAX6, SOSTDC1 and FAM20B using Sanger sequencing. The data were analyzed using pearson chi-square test with theoretical frequency ? 5. For theoretical frequency less than 5 but at least 1 (?20% cell), the data were analyzed by continuity correction. For the rest, Fisher's Exact test was used. A P-value

SUBMITTER: Liu S

PROVIDER: S-EPMC6537368 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature

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Lack of association between PAX6/SOSTDC1/FAM20B gene polymorphisms and mesiodens.

Liu Shanshan S Li Jiancheng J Xu Jincheng J Liao Shengkai S Chen Yongfeng Y Zhang Rongxiu R Tian Ruixue R Zhang Kai K

BMC oral health 20190527 1

<h4>Background</h4>The purpose of this study was to analyze the association between the genetic polymorphism of genes (PAX6, SOSTDC1and FAM20B) and the susceptibility to mesiodens.<h4>Methods</h4>This study was carried out on 50 patients with mesiodens and 50 controls. The family history of each patient with mesiodens were recorded. Genomic DNA was extracted from saliva samples, and single nucleotide polymorphisms were detected in all exons and exon/intron boundaries of PAX6, SOSTDC1 and FAM20B ...[more]

PMID: 31133012

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