Dataset Information

Comprehensive analysis of key genes and microRNAs in radioresistant nasopharyngeal carcinoma.

ABSTRACT:

Background

Radioresistance is one of the main obstacle limiting the therapeutic efficacy and prognosis of patients, the molecular mechanisms of radioresistance is still unclear. The purpose of this study was to identify the key genes and miRNAs and to explore their potential molecular mechanisms in radioresistant nasopharyngeal carcinoma.

Methods

In this study, we analysis the differentially expressed genes and microRNA based on the database of GSE48501 and GSE48502, and then employed bioinformatics to analyze the pathways and GO terms in which DEGs and DEMS target genes are involved. Moreover, Construction of protein-protein interaction network and identification of hub genes. Finally, analyzed the biological networks for validated target gene of hub miRNAs.

Results

A total of 373 differentially expressed genes (DEGs) and 14 differentially expressed microRNAs (DEMs) were screened out. The up-regulated gene JUN was overlap both in DEGs and publicly available studies, which was potentially targeted by three miRNAs, including hsa-miR-203, hsa-miR-24 and hsa-miR-31. Moreover, Pathway analysis showed that both up-regulated gene and DEMs target genes were enriched in TGF-beta signaling pathway, Hepatitis B, Pathways in cancer and p53 signaling pathway. Finally, we further constructed protein-protein interaction network (PPI) of DEGs and analyzed the biological networks for above mentioned common miRNAs, the result indicated that JUN was a core hub gene in PPI network, hsa-miR-24 and its target gene were significantly enriched in P53 signaling pathway.

Conclusions

These results might provide new clues to improve the radiosensitivity of Nasopharyngeal Carcinoma.

SUBMITTER: Guo Y

PROVIDER: S-EPMC6537399 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Comprehensive analysis of key genes and microRNAs in radioresistant nasopharyngeal carcinoma.

Guo Ya Y Zhang Yang Y Zhang Shu Juan SJ Ma Yi Nan YN He Yun Y

BMC medical genomics 20190528 1

<h4>Background</h4>Radioresistance is one of the main obstacle limiting the therapeutic efficacy and prognosis of patients, the molecular mechanisms of radioresistance is still unclear. The purpose of this study was to identify the key genes and miRNAs and to explore their potential molecular mechanisms in radioresistant nasopharyngeal carcinoma.<h4>Methods</h4>In this study, we analysis the differentially expressed genes and microRNA based on the database of GSE48501 and GSE48502, and then empl ...[more]

PMID: 31138194

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Dataset Information

Comprehensive analysis of key genes and microRNAs in radioresistant nasopharyngeal carcinoma.

Background

Methods

Results

Conclusions

Publications

Comprehensive analysis of key genes and microRNAs in radioresistant nasopharyngeal carcinoma.

Similar Datasets

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