The role of ubiquitin-specific peptidases in cancer progression.
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ABSTRACT:
SUBMITTER: Young MJ
PROVIDER: S-EPMC6537419 | biostudies-literature | 2019 May
REPOSITORIES: biostudies-literature
Publications
The role of ubiquitin-specific peptidases in cancer progression.
Young Ming-Jer MJ Hsu Kai-Cheng KC Lin Tony Eight TE Chang Wen-Chang WC Hung Jan-Jong JJ
Journal of biomedical science 20190527 1
Protein ubiquitination is an important mechanism for regulating the activity and levels of proteins under physiological conditions. Loss of regulation by protein ubiquitination leads to various diseases, such as cancer. Two types of enzymes, namely, E1/E2/E3 ligases and deubiquitinases, are responsible for controlling protein ubiquitination. The ubiquitin-specific peptidases (USPs) are the main members of the deubiquitinase family. Many studies have addressed the roles of USPs in various disease ...[more]
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