Ontology highlight
ABSTRACT:
SUBMITTER: Kim W
PROVIDER: S-EPMC6537650 | biostudies-literature | 2019 May
REPOSITORIES: biostudies-literature
Kim Wonkyong W Choi Jee Soo JS Kim Daun D Shin Doohang D Suk Shinae S Lee Younghoon Y
Molecules and cells 20190501 5
Many small RNAs (sRNAs) regulate gene expression by base pairing to their target messenger RNAs (mRNAs) with the help of Hfq in <i>Escherichia coli</i>. The sRNA DsrA activates translation of the <i>rpoS</i> mRNA in an Hfq-dependent manner, but this activation ability was found to partially bypass Hfq when DsrA is overproduced. The precise mechanism by which DsrA bypasses Hfq is unknown. In this study, we constructed strains lacking all three <i>rpoS</i>-activating sRNAs (i.e., ArcZ, DsrA, and R ...[more]