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Sequence-based HLA-A, B, C, DP, DQ, and DR typing of 496 adults from San Diego, California, USA.

ABSTRACT: DNA sequence-based typing at the HLA-A, -B, -C, -DPB1, -DQA1, -DQB1, and -DRB1 loci was performed on 496 healthy adult donors from San Diego, California, to characterize allele frequencies in support of studies of T cell responses to common allergens. Deviations from Hardy Weinberg proportions were detected at each locus except A and C. Several alleles were found in more than 15% of individuals, including the class II alleles DPB1?02:01, DPB1?04:01, DQA1?01:02, DQA1?05:01, DQB1?03:01, and the class I allele A?02:01. Genotype data will be available in the Allele Frequencies Net Database (AFND 3562).

SUBMITTER: Moore E

PROVIDER: S-EPMC6537871 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature

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Sequence-based HLA-A, B, C, DP, DQ, and DR typing of 496 adults from San Diego, California, USA.

Moore Eugene E Grifoni Alba A Weiskopf Daniela D Schulten Veronique V Arlehamn Cecilia S Lindestam CSL Angelo Michael M Pham John J Leary Shay S Sidney John J Broide David D Frazier April A Phillips Elizabeth E Mallal Simon S Mack Steven J SJ Sette Alessandro A

Human immunology 20180929 12

DNA sequence-based typing at the HLA-A, -B, -C, -DPB1, -DQA1, -DQB1, and -DRB1 loci was performed on 496 healthy adult donors from San Diego, California, to characterize allele frequencies in support of studies of T cell responses to common allergens. Deviations from Hardy Weinberg proportions were detected at each locus except A and C. Several alleles were found in more than 15% of individuals, including the class II alleles DPB1∗02:01, DPB1∗04:01, DQA1∗01:02, DQA1∗05:01, DQB1∗03:01, and the cl ...[more]

PMID: 30278218

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