Ontology highlight
ABSTRACT:
SUBMITTER: Pepple KL
PROVIDER: S-EPMC6538052 | biostudies-literature | 2018 Dec
REPOSITORIES: biostudies-literature
Ophthalmology 20180704 12
The interleukin (IL)-23/IL-17 axis plays a central role in the pathogenesis of immune-mediated diseases such as psoriasis, psoriatic arthritis, Crohn's disease, and uveitis. Therefore, targeting the IL-23/IL-17 axis has become the focus of multiple clinical trials for drug development in patients with autoimmune diseases. We briefly describe the biology of the IL-23/IL-17 axis and its relevance to the pathogenesis of experimental and clinical uveitis, and review the monoclonal antibody therapies ...[more]