Dissociable laminar profiles of concurrent bottom-up and top-down modulation in the human visual cortex.

ABSTRACT: Recent developments in human neuroimaging make it possible to non-invasively measure neural activity from different cortical layers. This can potentially reveal not only which brain areas are engaged by a task, but also how. Specifically, bottom-up and top-down responses are associated with distinct laminar profiles. Here, we measured lamina-resolved fMRI responses during a visual task designed to induce concurrent bottom-up and top-down modulations via orthogonal manipulations of stimulus contrast and feature-based attention. BOLD responses were modulated by both stimulus contrast (bottom-up) and by engaging feature-based attention (top-down). Crucially, these effects operated at different cortical depths: Bottom-up modulations were strongest in the middle cortical layer and weaker in dee

SUBMITTER: Lawrence SJ 

PROVIDER: S-EPMC6538372 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature