Ontology highlight
ABSTRACT:
SUBMITTER: Zubcevic L
PROVIDER: S-EPMC6538378 | biostudies-literature | 2019 May
REPOSITORIES: biostudies-literature
eLife 20190509
Temperature-sensitive transient receptor potential vanilloid (thermoTRPV) channels are activated by ligands and heat, and are involved in various physiological processes. ThermoTRPV channels possess a large cytoplasmic ring consisting of N-terminal ankyrin repeat domains (ARD) and C-terminal domains (CTD). The cytoplasmic inter-protomer interface is unique and consists of a CTD coiled around a β-sheet which makes contacts with the neighboring ARD. Despite much existing evidence that the cytoplas ...[more]