Ontology highlight
ABSTRACT:
SUBMITTER: Karandikar SH
PROVIDER: S-EPMC6538383 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
JCI insight 20190314
MHC I-restricted epitopes of chicken ovalbumin (OVA) were originally identified using CD8 T cells as probes. Here, using bioinformatics tools, we identify four additional epitopes in OVA in addition to a cryptic epitope. Each new epitope is presented in vivo, as deduced from the lack of CD8 response to it in OVA-transgenic mice. In addition, CD8 responses to the known and novel epitopes are examined in C57BL/6 mice exposed to the OVA-expressing tumor E.G7 in several ways. No responses to any epi ...[more]