Regulation of the unfolded protein response in yeast by oxidative stress.
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ABSTRACT:
SUBMITTER: Guerra-Moreno A
PROVIDER: S-EPMC6538422 | biostudies-literature | 2019 May
REPOSITORIES: biostudies-literature
Publications
Regulation of the unfolded protein response in yeast by oxidative stress.
Guerra-Moreno Angel A Ang Jessie J Welsch Hendrik H Jochem Marco M Hanna John J
FEBS letters 20190430 10
In the unfolded protein response (UPR), Ire1 activates Hac1 to coordinate the transcription of hundreds of genes to mitigate ER stress. Recent work in Caenorhabditis elegans suggests that oxidative stress inhibits this canonical Ire1 signalling pathway, activating instead an antioxidant stress response. We sought to determine whether this novel mode of UPR function also existed in yeast, where Ire1 has been best characterized. We show that the yeast UPR is also subject to inhibition by oxidative ...[more]
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