Ontology highlight
ABSTRACT:
SUBMITTER: Singh S
PROVIDER: S-EPMC6538489 | biostudies-literature | 2019 May
REPOSITORIES: biostudies-literature
Singh Snahlata S Elenio Emily E Leu Nicolae A NA Romano Rose-Anne RA Vaughan Andrew E AE DeRiso Jennifer J Surendran Kameswaran K Chakrabarti Rumela R
FEBS letters 20190501 10
Elf5 is a transcription factor known to regulate critical developmental processes and has been shown to act as a tumour suppressor in multiple cancers. Elf5 knockout mice are embryonically lethal, limiting in vivo studies pertaining to its function. Moreover, haploinsufficiency of Elf5 limits the use of current mouse models to investigate adult tissue distribution of Elf5. Here, we successfully generated Elf5<sup>Cre</sup><sup>ERT</sup><sup>2-</sup><sup>GFP</sup> bacterial artificial chromosome ...[more]