Ontology highlight
ABSTRACT:
SUBMITTER: Kurihara T
PROVIDER: S-EPMC6538626 | biostudies-literature | 2019 May
REPOSITORIES: biostudies-literature
Kurihara Toshiaki T Matsuda Sachiko S Nakamura Yuki Y Suzuki Shunichi S Fuchimoto Daiichiro D Onishi Akira A Saeki Kohei K Nakagawa Takayuki T Fujiwara Reina R Kamata Masatoshi M Kuramoto Junko J Kameyama Kaori K Sekino Masaki M Kusakabe Moriaki M Hayashida Tetsu T Jinno Hiromitsu H Kitagawa Yuko Y
Scientific reports 20190528 1
Lymph node metastasis occurs via the migration of cancer cells through the lymphatic system. Sentinel lymph node (SLN) biopsy is a common diagnostic strategy. SLNs have been studied using healthy rodents and large animals without metastasis. Here we used immunodeficient swine to establish a model of lymph node metastasis. We used RAG2-knockout immunodeficient swine. A431 human epithelial carcinoma cells expressing green fluorescent protein were injected subcutaneously into the posterior sides of ...[more]