Ontology highlight
ABSTRACT:
SUBMITTER: Pietila M
PROVIDER: S-EPMC6538630 | biostudies-literature | 2019 May
REPOSITORIES: biostudies-literature
Nature communications 20190528 1
The human epidermal growth factor receptor 2 (HER2) is an oncogene targeted by several kinase inhibitors and therapeutic antibodies. While the endosomal trafficking of many other receptor tyrosine kinases is known to regulate their oncogenic signalling, the prevailing view on HER2 is that this receptor is predominantly retained on the cell surface. Here, we find that sortilin-related receptor 1 (SORLA; SORL1) co-precipitates with HER2 in cancer cells and regulates HER2 subcellular distribution b ...[more]