Ontology highlight
ABSTRACT:
SUBMITTER: Rosenbaum M
PROVIDER: S-EPMC6538646 | biostudies-literature | 2019 May
REPOSITORIES: biostudies-literature
Rosenbaum Marc M Gewies Andreas A Pechloff Konstanze K Heuser Christoph C Engleitner Thomas T Gehring Torben T Hartjes Lara L Krebs Sabrina S Krappmann Daniel D Kriegsmann Mark M Weichert Wilko W Rad Roland R Kurts Christian C Ruland Jürgen J
Nature communications 20190528 1
Regulatory T cells (Tregs) have crucial functions in the inhibition of immune responses. Their development and suppressive functions are controlled by the T cell receptor (TCR), but the TCR signaling mechanisms that mediate these effects remain ill-defined. Here we show that CARD11-BCL10-MALT1 (CBM) signaling mediates TCR-induced NF-κB activation in Tregs and controls the conversion of resting Tregs to effector Tregs under homeostatic conditions. However, in inflammatory milieus, cytokines can b ...[more]