Cynomolgus macaque IL37 polymorphism and control of SIV infection.

ABSTRACT: The association between gene polymorphisms and plasma virus load at the set point (SP-PVL) was investigated in Mauritian macaques inoculated with SIV. Among 44 macaques inoculated with 50 AID50, six individuals were selected: three with SP-PVL among the highest and three with SP-PVL among the lowest. The exons of 390 candidate genes of these six animals were sequenced. Twelve non-synonymous single nucleotide polymorphisms (NS-SNPs) lying in nine genes potentially associated with PVL were genotyped in 23 animals. Three NS-SNPs with probabilities of association with PVL less than 0.05 were genotyped in a total of 44 animals. One NS-SNP lying in exon 1 of the IL37 gene displayed a significant association (p?=?3.33?×?10-4) and a strong odds ratio (19.52). Multiple linear regression modeling revealed three significant predictors of SP-PVL, including the IL37 exon 1 NS-SNP (p?=?0.0004) and the MHC Class IB haplotypes M2 (p?=?0.0007) and M6 (p?=?0.0013). These three factors in conjunction explained 48% of the PVL variance (p?=?4.8?×?10-6). The potential role of IL37 in the control of SIV infection is discussed.

SUBMITTER: Shiina T 

PROVIDER: S-EPMC6538695 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature