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Chemical Constituents from Mentha haplocalyx Briq. (Mentha canadensis L.) and Their ?-Glucosidase Inhibitory Activities.

ABSTRACT: Mentha haplocalyx (Mentha canadensis) is widely used as a medicinal plant in traditional Chinese medicine, and the extracts of its aerial parts are found to significantly inhibit the activity of ?-glucosidase with an IC₅₀ value of 21.0 ?g/mL. Bioactivity-guided isolation of the extracts afforded two new compounds (1 and 2), together with 23 known ones (3-25). Their structures were established by extensive spectroscopic analyses (1D and 2D NMR, MS, IR and UV). Compounds 1-17 and 21-25 were evaluated for their ?-glucosidase inhibitory activities. Compound 11 was the most active ones with an IC₅₀ values of 83.4 ?M. These results verify the ?-glucosidase inhibitory activity of M. haplocalyx (M. canadensis) and specify its active compounds for the first time.

SUBMITTER: He XF

PROVIDER: S-EPMC6538733 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature

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Chemical Constituents from Mentha haplocalyx Briq. (Mentha canadensis L.) and Their α-Glucosidase Inhibitory Activities.

He Xiao-Feng XF Geng Chang-An CA Huang Xiao-Yan XY Ma Yun-Bao YB Zhang Xue-Mei XM Chen Ji-Jun JJ

Natural products and bioprospecting 20190429 3

Mentha haplocalyx (Mentha canadensis) is widely used as a medicinal plant in traditional Chinese medicine, and the extracts of its aerial parts are found to significantly inhibit the activity of α-glucosidase with an IC<sub>50</sub> value of 21.0 μg/mL. Bioactivity-guided isolation of the extracts afforded two new compounds (1 and 2), together with 23 known ones (3-25). Their structures were established by extensive spectroscopic analyses (1D and 2D NMR, MS, IR and UV). Compounds 1-17 and 21-25 ...[more]

PMID: 31037617

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Dataset Information

Chemical Constituents from Mentha haplocalyx Briq. (Mentha canadensis L.) and Their ?-Glucosidase Inhibitory Activities.

Publications

Chemical Constituents from Mentha haplocalyx Briq. (Mentha canadensis L.) and Their α-Glucosidase Inhibitory Activities.

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