Dataset Information

Deep Learning and Multiplex Networks for Accurate Modeling of Brain Age.

ABSTRACT: Recent works have extensively investigated the possibility to predict brain aging from T1-weighted MRI brain scans. The main purposes of these studies are the investigation of subject-specific aging mechanisms and the development of accurate models for age prediction. Deviations between predicted and chronological age are known to occur in several neurodegenerative diseases; as a consequence, reaching higher levels of age prediction accuracy is of paramount importance to develop diagnostic tools. In this work, we propose a novel complex network model for brain based on segmenting T1-weighted MRI scans in rectangular boxes, called patches, and measuring pairwise similarities using Pearson's correlation to define a subject-specific network. We fed a deep neural network with nodal metrics, evaluating both the intensity and the uniformity of connections, to predict subjects' ages. Our model reaches high accuracies which compare favorably with state-of-the-art approaches. We observe that the complex relationships involved in this brain description cannot be accurately modeled with standard machine learning approaches, such as Ridge and Lasso regression, Random Forest, and Support Vector Machines, instead a deep neural network has to be used.

SUBMITTER: Amoroso N

PROVIDER: S-EPMC6538815 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature

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Publications

Deep Learning and Multiplex Networks for Accurate Modeling of Brain Age.

Amoroso Nicola N La Rocca Marianna M Bellantuono Loredana L Diacono Domenico D Fanizzi Annarita A Lella Eufemia E Lombardi Angela A Maggipinto Tommaso T Monaco Alfonso A Tangaro Sabina S Bellotti Roberto R

Frontiers in aging neuroscience 20190522

Recent works have extensively investigated the possibility to predict brain aging from T1-weighted MRI brain scans. The main purposes of these studies are the investigation of subject-specific aging mechanisms and the development of accurate models for age prediction. Deviations between predicted and chronological age are known to occur in several neurodegenerative diseases; as a consequence, reaching higher levels of age prediction accuracy is of paramount importance to develop diagnostic tools ...[more]

PMID: 31178715

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Project description:Brain age is an imaging-based biomarker with excellent feasibility for characterizing individual brain health and may serve as a single quantitative index for clinical and domain-specific usage. Brain age has been successfully estimated using extensive neuroimaging data from healthy participants with various feature extraction and conventional machine learning (ML) approaches. Recently, several end-to-end deep learning (DL) analytical frameworks have been proposed as alternative approaches to predict individual brain age with higher accuracy. However, the optimal approach to select and assemble appropriate input feature sets for DL analytical frameworks remains to be determined. In the Predictive Analytics Competition 2019, we proposed a hierarchical analytical framework which first used ML algorithms to investigate the potential contribution of different input features for predicting individual brain age. The obtained information then served as a priori knowledge for determining the input feature sets of the final ensemble DL prediction model. Systematic evaluation revealed that ML approaches with multiple concurrent input features, including tissue volume and density, achieved higher prediction accuracy when compared with approaches with a single input feature set [Ridge regression: mean absolute error (MAE) = 4.51 years, R 2 = 0.88; support vector regression, MAE = 4.42 years, R 2 = 0.88]. Based on this evaluation, a final ensemble DL brain age prediction model integrating multiple feature sets was constructed with reasonable computation capacity and achieved higher prediction accuracy when compared with ML approaches in the training dataset (MAE = 3.77 years; R 2 = 0.90). Furthermore, the proposed ensemble DL brain age prediction model also demonstrated sufficient generalizability in the testing dataset (MAE = 3.33 years). In summary, this study provides initial evidence of how-to efficiency for integrating ML and advanced DL approaches into a unified analytical framework for predicting individual brain age with higher accuracy. With the increase in large open multiple-modality neuroimaging datasets, ensemble DL strategies with appropriate input feature sets serve as a candidate approach for predicting individual brain age in the future.

Dataset Information

Deep Learning and Multiplex Networks for Accurate Modeling of Brain Age.

Publications

Deep Learning and Multiplex Networks for Accurate Modeling of Brain Age.

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