Keeping crispr in check: diverse mechanisms of phage-encoded anti-crisprs.
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ABSTRACT:
SUBMITTER: Trasanidou D
PROVIDER: S-EPMC6538845 | biostudies-literature | 2019 May
REPOSITORIES: biostudies-literature
Publications
Keeping crispr in check: diverse mechanisms of phage-encoded anti-crisprs.
Trasanidou Despoina D Gerós Ana Sousa AS Mohanraju Prarthana P Nieuwenweg Anna Cornelia AC Nobrega Franklin L FL Staals Raymond H J RHJ
FEMS microbiology letters 20190501 9
CRISPR-Cas represents the only adaptive immune system of prokaryotes known to date. These immune systems are widespread among bacteria and archaea, and provide protection against invasion of mobile genetic elements, such as bacteriophages and plasmids. As a result of the arms-race between phages and their prokaryotic hosts, phages have evolved inhibitors known as anti-CRISPR (Acr) proteins to evade CRISPR immunity. In the recent years, several Acr proteins have been described in both temperate a ...[more]
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