Ontology highlight
ABSTRACT:
SUBMITTER: DeSmet M
PROVIDER: S-EPMC6538939 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
Virology 20180606
The papillomavirus (PV) E2 protein activates transcription and replication by recruiting cellular proteins and the E1 DNA helicase to their binding sites in the viral genome. We recently demonstrated that phosphorylation of tyrosine 102 in the bovine papillomavirus (BPV-1) E2 protein restricts these activities and that fibroblast growth factor receptor-3 (FGFR3) tyrosine kinase binds PV E2. Expression of FGFR3 decreased viral replication with both wild-type and the phenylalanine substitution at ...[more]