Ontology highlight
ABSTRACT:
SUBMITTER: Carvalho Junior AR
PROVIDER: S-EPMC6539033 | biostudies-literature | 2019 May
REPOSITORIES: biostudies-literature
Carvalho Junior Alexsander Rodrigues AR Martins Arthur Lima de Berredo ALB Cutrim Brenda da Silva BDS Santos Deivid Martins DM Maia Hermerson Sousa HS Silva Mari Silma Maia da MSMD Zagmignan Adrielle A Silva Maria Raimunda Chagas MRC Monteiro Cristina de Andrade CA Guilhon Giselle Maria Skelding Pinheiro GMSP Cantanhede Filho Antônio José AJ Nascimento da Silva Luís Cláudio LC
Molecules (Basel, Switzerland) 20190507 9
The occurrence of damage on bacterial DNA (mediated by antibiotics, for example) is intimately associated with the activation of the SOS system. This pathway is related to the development of mutations that might result in the acquisition and spread of resistance and virulence factors. The inhibition of the SOS response has been highlighted as an emerging resource, in order to reduce the emergence of drug resistance and tolerance. Herein, we evaluated the ability of betulinic acid (BA), a plant-d ...[more]