Ontology highlight
ABSTRACT:
SUBMITTER: Maass C
PROVIDER: S-EPMC6539699 | biostudies-literature | 2019 May
REPOSITORIES: biostudies-literature
Maass Christian C Sorensen Nathan B NB Himmelfarb Jonathan J Kelly Edward J EJ Stokes Cynthia L CL Cirit Murat M
CPT: pharmacometrics & systems pharmacology 20190409 5
Drug-induced kidney injury, a major cause of acute kidney injury, results in progressive kidney disease and is linked to increased mortality in hospitalized patients. Primary injury sites of drug-induced kidney injury are proximal tubules. Clinically, kidney injury molecule-1, an established tubule-specific biomarker, is monitored to assess the presence and progression of injury. The ability to accurately predict drug-related nephrotoxicity preclinically would reduce patient burden and drug attr ...[more]