Ontology highlight
ABSTRACT:
SUBMITTER: Valaskova P
PROVIDER: S-EPMC6539717 | biostudies-literature | 2019 May
REPOSITORIES: biostudies-literature
Valaskova Petra P Dvorak Ales A Lenicek Martin M Zizalova Katerina K Kutinova-Canova Nikolina N Zelenka Jaroslav J Cahova Monika M Vitek Libor L Muchova Lucie L
International journal of molecular sciences 20190509 9
Decreased inflammatory status has been reported in subjects with mild unconjugated hyperbilirubinemia. However, mechanisms of the anti-inflammatory actions of bilirubin (BR) are not fully understood. The aim of this study is to assess the role of BR in systemic inflammation using hyperbilirubinemic Gunn rats as well as their normobilirubinemic littermates and further in primary hepatocytes. The rats were treated with lipopolysaccharide (LPS, 6 mg/kg intraperitoneally) for 12 h, their blood and l ...[more]