Control of multilayer biological networks and applied to target identification of complex diseases.

ABSTRACT:

Background

Networks have been widely used to model the structures of various biological systems. The ultimate aim of research on biological networks is to steer biological system structures to desired states by manipulating signals. Despite great advances in the linear control of single-layer networks, it has been observed that many complex biological systems have a multilayer networked structure and extremely complicated nonlinear processes.

Result

In this study, we propose a general framework for controlling nonlinear dynamical systems with multilayer networked structures by formulating the problem as a minimum union optimization problem. In particular, we offer a novel approach for identifying the minimal driver nodes that can steer a multilayered nonlinear dynamical syst

SUBMITTER: Zheng W 

PROVIDER: S-EPMC6540418 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature