Associating somatic mutations to clinical outcomes: a pan-cancer study of survival time.
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ABSTRACT:
SUBMITTER: Little P
PROVIDER: S-EPMC6540540 | biostudies-literature | 2019 May
REPOSITORIES: biostudies-literature
Publications
Associating somatic mutations to clinical outcomes: a pan-cancer study of survival time.
Little Paul P Lin Dan-Yu DY Sun Wei W
Genome medicine 20190528 1
We developed subclone multiplicity allocation and somatic heterogeneity (SMASH), a new statistical method for intra-tumor heterogeneity (ITH) inference. SMASH is tailored to the purpose of large-scale association studies with one tumor sample per patient. In a pan-cancer study of 14 cancer types, we studied the associations between survival time and ITH quantified by SMASH, together with other features of somatic mutations. Our results show that ITH is associated with survival time in several ca ...[more]
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