Ontology highlight
ABSTRACT:
SUBMITTER: Negron A
PROVIDER: S-EPMC6540809 | biostudies-literature | 2019 May
REPOSITORIES: biostudies-literature
Negron Austin A Robinson Rachel R RR Stüve Olaf O Forsthuber Thomas G TG
Cellular immunology 20181021
While it was long held that T cells were the primary mediators of multiple sclerosis (MS) pathogenesis, the beneficial effects observed in response to treatment with Rituximab (RTX), a monoclonal antibody (mAb) targeting CD20, shed light on a key contributor to MS that had been previously underappreciated: B cells. This has been reaffirmed by results from clinical trials testing the efficacy of subsequently developed B cell-depleting mAbs targeting CD20 as well as studies revisiting the effects ...[more]