Ontology highlight
ABSTRACT:
SUBMITTER: Zhou S
PROVIDER: S-EPMC6541463 | biostudies-literature | 2019 May
REPOSITORIES: biostudies-literature
Zhou Sitong S Giannetto Michael M DeCourcey James J Kang Hongyi H Kang Ning N Li Yizeng Y Zheng Suilan S Zhao Hetince H Simmons William R WR Wei Helen S HS Bodine David M DM Low Philip S PS Nedergaard Maiken M Wan Jiandi J
Science advances 20190529 5
The tight coupling between cerebral blood flow and neural activity is a key feature of normal brain function and forms the basis of functional hyperemia. The mechanisms coupling neural activity to vascular responses, however, remain elusive despite decades of research. Recent studies have shown that cerebral functional hyperemia begins in capillaries, and red blood cells (RBCs) act as autonomous regulators of brain capillary perfusion. RBCs then respond to local changes of oxygen tension (<i>P</ ...[more]