Early divergence of mutational processes in human fetal tissues.
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ABSTRACT:
SUBMITTER: Kuijk E
PROVIDER: S-EPMC6541467 | biostudies-literature | 2019 May
REPOSITORIES: biostudies-literature
Publications
Early divergence of mutational processes in human fetal tissues.
Kuijk Ewart E Blokzijl Francis F Jager Myrthe M Besselink Nicolle N Boymans Sander S Chuva de Sousa Lopes Susana M SM van Boxtel Ruben R Cuppen Edwin E
Science advances 20190529 5
A developing human fetus needs to balance rapid cellular expansion with maintaining genomic stability. Here, we accurately quantified and characterized somatic mutation accumulation in fetal tissues by analyzing individual stem cells from human fetal liver and intestine. Fetal mutation rates were about fivefold higher than in tissue-matched adult stem cells. The mutational landscape of fetal intestinal stem cells resembled that of adult intestinal stem cells, while the mutation spectrum of fetal ...[more]
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