Ontology highlight
ABSTRACT:
SUBMITTER: Marshall SA
PROVIDER: S-EPMC6541611 | biostudies-literature | 2019 May
REPOSITORIES: biostudies-literature
Nature communications 20190529 1
The UbiX-UbiD enzymes are widespread in microbes, acting in concert to decarboxylate alpha-beta unsaturated carboxylic acids using a highly modified flavin cofactor, prenylated FMN (prFMN). UbiX serves as the flavin prenyltransferase, extending the isoalloxazine ring system with a fourth non-aromatic ring, derived from sequential linkage between a dimethylallyl moiety and the FMN N5 and C6. Using structure determination and solution studies of both dimethylallyl monophosphate (DMAP) and dimethya ...[more]