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Summary data of serum concentrations of 32 persistent organic pollutants in young adults in relation to summary scores of persistent organic pollutants.

ABSTRACT: This data article presents mean serum concentrations (wet weight and lipid standardized) of 32 persistent organic pollutants (POPs) detected in >75% of participants of the Coronary Artery Risk Development in Young Adults (CARDIA) study across levels of POPs scores, and their corresponding coefficients of determination. POPs scores were calculated as: A) the sum of each participant's log-transformed POPs concentrations (? of log Pops], or B) as the sum of the participants' log-transformed concentrations of each POP divided by the groups' standard deviation of the corresponding log-transformed POP (POPs summary score. Scores were calculated for both wet weight and lipid standardized concentrations and for all 32 POPs and for PCBs and organochlorine pesticides separately. POPs summary scores analyses were used in the article "Organochlorine pesticides and polychlorinated biphenyls (PCBs) in early adulthood and blood lipids over a 23-year follow-up" [Suarez-Lopez et al., 2018].

SUBMITTER: Suarez-Lopez JR

PROVIDER: S-EPMC6541699 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature

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Summary data of serum concentrations of 32 persistent organic pollutants in young adults in relation to summary scores of persistent organic pollutants.

Suarez-Lopez Jose R JR Gross Myron D MD Lee Duk-Hee DH

Data in brief 20190307

This data article presents mean serum concentrations (wet weight and lipid standardized) of 32 persistent organic pollutants (POPs) detected in >75% of participants of the Coronary Artery Risk Development in Young Adults (CARDIA) study across levels of POPs scores, and their corresponding coefficients of determination. POPs scores were calculated as: A) the sum of each participant's log-transformed POPs concentrations (∑ of log Pops], or B) as the sum of the participants' log-transformed concent ...[more]

PMID: 31193752

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Project description:Although the production and use of some persistent organic pollutants (POPs) have been banned or highly restricted, human exposure remains a subject of investigation due to their environmental persistence. Physiological changes during pregnancy may affect the disposition of POPs in the mother's body, and thus fetal exposure. Changes in serum concentrations of organochlorine pesticides (OCPs) and polychlorinated biphenyls (PCBs) across pregnancy trimesters, and trans-placental transfer to the fetus were investigated. Seventy-nine pregnant women in Trujillo, Peru were recruited in the first trimester of pregnancy, and provided blood samples for the analysis of 35 PCB congeners, 9 OCPs, and 11 polybrominated biphenyl diethers (PBDEs). Subsequently, maternal blood samples were collected in the second (n=64) and third trimesters (n=59), and cord blood samples (n=50) were collected at delivery. There were statistically significant changes across trimesters (p<0.05) for both fresh weight (increase) and lipid adjusted concentrations (decrease) of hexachlorobenzene (HCB), 2,2-Bis(4-chlorophenyl)-1,1-dichloroethene (p,p'-DDE), PCB-74, 118, 138-158, 153, 170, 180 and 194. Fresh weight concentrations of these POPs increased from first to third trimester by 10-28%. On the other hand lipid adjusted concentrations decreased from first to third trimester by 16-28%. Serum lipids increased from first to third trimester by 53% indicating the dilution of the POPs in the lipids. Concentrations of 2,2-Bis(4-chlorophenyl)-1,1,1-trichloroethane (p,p'-DDT), its metabolite p,p'-DDE, PCB-118, 138-158, 153, 170 and 180 above their limits of detection were measured in >60% of cord serum samples. Intra-individual correlations in maternal serum concentrations were high for most of the POPs (?=0.62-0.99; p<0.05) while correlations between maternal and cord serum concentrations were also high (?=0.68-0.99; p<0.05). Results indicate that the disposition in the body and blood concentrations of POPs may change during pregnancy, and show trans-placental transfer of DDT, DDE and PCBs.

Dataset Information

Summary data of serum concentrations of 32 persistent organic pollutants in young adults in relation to summary scores of persistent organic pollutants.

Publications

Summary data of serum concentrations of 32 persistent organic pollutants in young adults in relation to summary scores of persistent organic pollutants.

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