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Total hip arthroplasty for a woman with hemophilia A -case report.

ABSTRACT: Hemophilia A is a congenital bleeding disorder caused by an X-linked hereditary pattern. Female hemophilia A carriers are usually asymptomatic, although some have far lower levels of clotting factor because more X chromosomes with the normal gene are switched off, a phenomenon referred to as "lyonization." During a medical checkup at our hospital, a 56-year-old Japanese woman with coxalgia was also diagnosed as an obligate hemophilia A carrier based on World Federation of Hemophilia criteria. She underwent total hip arthroplasty using blood product coagulation factor VIII to address her hemophilia. Immediate female relatives (mother, sisters, daughters) of a person with hemophilia should have their clotting factor levels checked, especially prior to any invasive intervention or childbirth, or if any symptoms occur.

SUBMITTER: Kanda A

PROVIDER: S-EPMC6541728 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature

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Total hip arthroplasty for a woman with hemophilia A -case report.

Kanda Akio A Kaneko Kazuo K Obayashi Osamu O Mogami Atsuhiko A Morohashi Itaru I

Annals of medicine and surgery (2012) 20190524

Hemophilia A is a congenital bleeding disorder caused by an X-linked hereditary pattern. Female hemophilia A carriers are usually asymptomatic, although some have far lower levels of clotting factor because more X chromosomes with the normal gene are switched off, a phenomenon referred to as "lyonization." During a medical checkup at our hospital, a 56-year-old Japanese woman with coxalgia was also diagnosed as an obligate hemophilia A carrier based on World Federation of Hemophilia criteria. Sh ...[more]

PMID: 31193739

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