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Characterization of Differential Dynamics, Specificity, and Allostery of Lipoxygenase Family Members.


ABSTRACT: Accurate modeling of structural dynamics of proteins and their differentiation across different species can help us understand generic mechanisms of function shared by family members and the molecular basis of the specificity of individual members. We focused here on the family of lipoxygenases, enzymes that catalyze lipid oxidation, the mammalian and bacterial structures of which have been elucidated. We present a systematic method of approach for characterizing the sequence, structure, dynamics, and allosteric signaling properties of these enzymes using a combination of structure-based models and methods and bioinformatics tools applied to a data set of 88 structures. The analysis elucidates the signature dynamics of the lipoxygenase family and its differentiation among members, as well as key sites that enable its adaptation to specific substrate binding and allosteric activity.

SUBMITTER: Mikulska-Ruminska K 

PROVIDER: S-EPMC6541894 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature

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Characterization of Differential Dynamics, Specificity, and Allostery of Lipoxygenase Family Members.

Mikulska-Ruminska Karolina K   Shrivastava Indira I   Krieger James J   Zhang She S   Li Hongchun H   Bayır Hülya H   Wenzel Sally E SE   VanDemark Andrew P AP   Kagan Valerian E VE   Bahar Ivet I  

Journal of chemical information and modeling 20190228 5


Accurate modeling of structural dynamics of proteins and their differentiation across different species can help us understand generic mechanisms of function shared by family members and the molecular basis of the specificity of individual members. We focused here on the family of lipoxygenases, enzymes that catalyze lipid oxidation, the mammalian and bacterial structures of which have been elucidated. We present a systematic method of approach for characterizing the sequence, structure, dynamic  ...[more]

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