Ontology highlight
ABSTRACT:
SUBMITTER: Hinze L
PROVIDER: S-EPMC6541931 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
Hinze Laura L Pfirrmann Maren M Karim Salmaan S Degar James J McGuckin Connor C Vinjamur Divya D Sacher Joshua J Stevenson Kristen E KE Neuberg Donna S DS Orellana Esteban E Stanulla Martin M Gregory Richard I RI Bauer Daniel E DE Wagner Florence F FF Stegmaier Kimberly K Gutierrez Alejandro A
Cancer cell 20190401 4
Resistance to asparaginase, an antileukemic enzyme that depletes asparagine, is a common clinical problem. Using a genome-wide CRISPR/Cas9 screen, we found a synthetic lethal interaction between Wnt pathway activation and asparaginase in acute leukemias resistant to this enzyme. Wnt pathway activation induced asparaginase sensitivity in distinct treatment-resistant subtypes of acute leukemia, but not in normal hematopoietic progenitors. Sensitization to asparaginase was mediated by Wnt-dependent ...[more]