Dataset Information

Aging Does Not Affect Beta Modulation during Reaching Movements.

ABSTRACT: During movement, modulation of beta power occurs over the sensorimotor areas, with a decrease just before its start (event-related desynchronization, ERD) and a rebound after its end (event-related synchronization, ERS). We have recently found that the depth of ERD-to-ERS modulation increases during practice in a reaching task and the following day decreases to baseline levels. Importantly, the magnitude of the beta modulation increase during practice is highly correlated with the retention of motor skill tested the following day. Together with other evidence, this suggests that the increase of practice-related modulation depth may be the expression of sensorimotor cortex's plasticity. Here, we determine whether the practice-related increase of beta modulation depth is equally present in a group of younger and a group of older subjects during the performance of a 30-minute block of reaching movements. We focused our analyses on two regions of interest (ROIs): the left sensorimotor and the frontal region. Performance indices were significantly different in the two groups, with the movements of older subjects being slower and less accurate. Importantly, both groups presented a similar increase of the practice-related beta modulation depth in both ROIs in the course of the task. Peak latency analysis revealed a progressive delay of the ERS peak that correlated with the total movement time. Altogether, these findings support the notion that the depth of beta modulation in a reaching movement task does not depend on age and confirm previous findings that only ERS peak latency but not ERS magnitude is related to performance indices.

SUBMITTER: Ricci S

PROVIDER: S-EPMC6541950 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature

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Aging Does Not Affect Beta Modulation during Reaching Movements.

Ricci Serena S Ricci Serena S Mehraram Ramtin R Tatti Elisa E Nelson Aaron B AB Bossini-Baroggi Martina M Panday Priya P Lin Nancy N Ghilardi M Felice MF

Neural plasticity 20190515

During movement, modulation of beta power occurs over the sensorimotor areas, with a decrease just before its start (event-related desynchronization, ERD) and a rebound after its end (event-related synchronization, ERS). We have recently found that the depth of ERD-to-ERS modulation increases during practice in a reaching task and the following day decreases to baseline levels. Importantly, the magnitude of the beta modulation increase during practice is highly correlated with the retention of m ...[more]

PMID: 31223306

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Project description:Background and objectivesHuman motor control (HMC) has been hypothesized to involve state estimation, prediction and feedback control to overcome noise, delays and disturbances. However, the nature of communication between these processes, and, in particular, whether it is continuous or intermittent, is still an open issue. Depending on the nature of communication, the resulting control is referred to as continuous control (CC) or intermittent control (IC). While standard HMC theories are based on CC, IC has been argued to be more viable since it reduces computational and communication burden and agrees better with some experimental results. However, to be a feasible model for HMC, IC has to cope well with inaccurately modeled plants, which are common in daily life, as when lifting lighter than expected loads. While IC may involve event-driven triggering, it is generally assumed that refractory mechanisms in HMC set a lower limit on the interval between triggers. Hence, we focus on periodic IC, which addresses this lower limit and also facilitates analysis.Theoretical methods and resultsTheoretical stability criteria are derived for CC and IC of inaccurately modeled linear time-invariant systems with and without delays. Considering a simple muscle-actuated hand model with inaccurately modeled load, both CC and IC remain stable over most of the investigated range, and may become unstable only when the actual load is much smaller than expected, usually smaller than the minimum set by the actual mass of the forearm and hand. Neither CC nor IC is consistently superior to the other in terms of the range of loads over which the system remains stable.Numerical methods and resultsNumerical simulations of time-delayed reaching movements are presented and analyzed to evaluate the effects of model inaccuracies when the control and observer gains are time-dependent, as is assumed to occur in HMC. Both IC and CC agree qualitatively with previously published experimental results with inaccurately modeled plants. Thus, our study suggests that IC copes well with inaccurately modeled plants and is indeed a viable model for HMC.

Project description:Subthalamic nucleus (STN) beta-triggered adaptive deep brain stimulation (ADBS) has been shown to provide clinical improvement comparable to conventional continuous DBS (CDBS) with less energy delivered to the brain and less stimulation induced side effects. However, several questions remain unanswered. First, there is a normal physiological reduction of STN beta band power just prior to and during voluntary movement. ADBS systems will therefore reduce or cease stimulation during movement in people with Parkinson's disease and could therefore compromise motor performance compared to CDBS. Second, beta power was smoothed and estimated over a time period of 400 ms in most previous ADBS studies, but a shorter smoothing period could have the advantage of being more sensitive to changes in beta power, which could enhance motor performance. In this study, we addressed these two questions by evaluating the effectiveness of STN beta-triggered ADBS using a standard 400 ms and a shorter 200 ms smoothing window during reaching movements. Results from 13 people with Parkinson's disease showed that reducing the smoothing window for quantifying beta did lead to shortened beta burst durations by increasing the number of beta bursts shorter than 200 ms and more frequent switching on/off of the stimulator but had no behavioural effects. Both ADBS and CDBS improved motor performance to an equivalent extent compared to no DBS. Secondary analysis revealed that there were independent effects of a decrease in beta power and an increase in gamma power in predicting faster movement speed, while a decrease in beta event related desynchronization (ERD) predicted quicker movement initiation. CDBS suppressed both beta and gamma more than ADBS, whereas beta ERD was reduced to a similar level during CDBS and ADBS compared with no DBS, which together explained the achieved similar performance improvement in reaching movements during CDBS and ADBS. In addition, ADBS significantly improved tremor compared with no DBS but was not as effective as CDBS. These results suggest that STN beta-triggered ADBS is effective in improving motor performance during reaching movements in people with Parkinson's disease, and that shortening of the smoothing window does not result in any additional behavioural benefit. When developing ADBS systems for Parkinson's disease, it might not be necessary to track very fast beta dynamics; combining beta, gamma, and information from motor decoding might be more beneficial with additional biomarkers needed for optimal treatment of tremor.

Dataset Information

Aging Does Not Affect Beta Modulation during Reaching Movements.

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Aging Does Not Affect Beta Modulation during Reaching Movements.

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