Ontology highlight
ABSTRACT:
SUBMITTER: Pitzer EM
PROVIDER: S-EPMC6542333 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
Toxicological sciences : an official journal of the Society of Toxicology 20190601 2
Pyrethroids are synthetic insecticides that act acutely on voltage gated sodium channels to prolong channel opening and depolarization. Epidemiological studies find that exposure to pyrethroids are associated with neurological and developmental abnormalities in children. The long-term effects of type II pyrethroids, such as deltamethrin (DLM), on development have received little attention. We exposed Sprague-Dawley rats to DLM by gavage at doses of 0, 0.25, 0.5, and 1.0 mg/kg/day from postnatal ...[more]