Ontology highlight
ABSTRACT:
SUBMITTER: Danese E
PROVIDER: S-EPMC6542461 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
Clinical pharmacology and therapeutics 20190217 6
The cytochrome P450 (CYP)4F2 gene is known to influence mean coumarin dose. The aim of the present study was to undertake a meta-analysis at the individual patients level to capture the possible effect of ethnicity, gene-gene interaction, or other drugs on the association and to verify if inclusion of CYP4F2*3 variant into dosing algorithms improves the prediction of mean coumarin dose. We asked the authors of our previous meta-analysis (30 articles) and of 38 new articles retrieved by a systema ...[more]