Ontology highlight
ABSTRACT:
SUBMITTER: Cho WK
PROVIDER: S-EPMC6543815 | biostudies-literature | 2018 Jul
REPOSITORIES: biostudies-literature
Cho Won-Ki WK Spille Jan-Hendrik JH Hecht Micca M Lee Choongman C Li Charles C Grube Valentin V Cisse Ibrahim I II
Science (New York, N.Y.) 20180621 6400
Models of gene control have emerged from genetic and biochemical studies, with limited consideration of the spatial organization and dynamics of key components in living cells. We used live-cell superresolution and light-sheet imaging to study the organization and dynamics of the Mediator coactivator and RNA polymerase II (Pol II) directly. Mediator and Pol II each form small transient and large stable clusters in living embryonic stem cells. Mediator and Pol II are colocalized in the stable clu ...[more]