Ontology highlight
ABSTRACT:
SUBMITTER: Zhou R
PROVIDER: S-EPMC6543840 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Zhou Ru R Yazdanifar Mahboubeh M Roy Lopamudra Das LD Whilding Lynsey M LM Gavrill Artemis A Maher John J Mukherjee Pinku P
Frontiers in immunology 20190524
Antibody-derived chimeric antigen receptor (CAR) T cell therapy has achieved gratifying breakthrough in hematologic malignancies but has shown limited success in solid tumor immunotherapy. Monoclonal antibody, TAB004, specifically recognizes the aberrantly glycosylated tumor form of MUC1 (tMUC1) in all subtypes of breast cancer including 95% of triple-negative breast cancer (TNBC) while sparing recognition of normal tissue MUC1. We transduced human T cells with MUC28z, a chimeric antigen recepto ...[more]