Ontology highlight
ABSTRACT:
SUBMITTER: Gulko B
PROVIDER: S-EPMC6544027 | biostudies-literature | 2019 Feb
REPOSITORIES: biostudies-literature
Nature genetics 20181217 2
Here we ask the question "How much information do epigenomic datasets provide about human genomic function?" We consider nine epigenomic features across 115 cell types and measure information about function as a reduction in entropy under a probabilistic evolutionary model fitted to human and nonhuman primate genomes. Several epigenomic features yield more information in combination than they do individually. We find that the entropy in human genetic variation predominantly reflects a balance be ...[more]