Selection for depression-specific dementia cases with replication in two cohorts.
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ABSTRACT:
SUBMITTER: Royall DR
PROVIDER: S-EPMC6544211 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Publications
Selection for depression-specific dementia cases with replication in two cohorts.
Royall Donald R DR Palmer Raymond F RF
PloS one 20190531 5
The latent variable "δ" (for "dementia") provides an etiologically "agnostic" omnibus dementia severity metric capable of recognizing the dementing potential of any condition. Depressive symptoms are independent predictors of δ and are thereby implicated as "dementing". Serum resistin levels partially mediate the association between depressive symptoms and δ. We use a novel "off-diagonal" CHI SQ algorithm to demonstrate our ability to select individuals demented solely by depression's effect in ...[more]
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