Ontology highlight
ABSTRACT:
SUBMITTER: Felix TF
PROVIDER: S-EPMC6544344 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Felix Tainara F TF Lopez Lapa Rainer M RM de Carvalho Márcio M Bertoni Natália N Tokar Tomas T Oliveira Rogério A RA M Rodrigues Maria A MA Hasimoto Cláudia N CN Oliveira Walmar K WK Pelafsky Leonardo L Spadella César T CT Llanos Juan C JC F Silva Giovanni G Lam Wan L WL Rogatto Silvia Regina SR Amorim Luciana Schultz LS Drigo Sandra A SA Carvalho Robson F RF Reis Patricia P PP
PloS one 20190531 5
Despite progress in treatment strategies, only ~24% of pancreatic ductal adenocarcinoma (PDAC) patients survive >1 year. Our goal was to elucidate deregulated pathways modulated by microRNAs (miRNAs) in PDAC and Vater ampulla (AMP) cancers. Global miRNA expression was identified in 19 PDAC, 6 AMP and 25 paired, histologically normal pancreatic tissues using the GeneChip 4.0 miRNA arrays. Computational approaches were used for miRNA target prediction/identification of miRNA-regulated pathways. Ta ...[more]